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Vaccine Detail
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Vibrio cholerae hemA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Vibrio cholerae hemA mutant vaccine
- Target Pathogen: Vibrio cholerae
- Target Disease: Cholera
- Vaccine Ontology ID: VO_0002934
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rabbit
- hemA
gene engineering:
- Immunization Route: Oral immunization
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| Host Response |
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Rabbit Response
- Persistence: A hemA mutant is highly attenuated in rabbits (Ravichandran et al., 2006).
- Efficacy: A hemA mutant induces protection in rabbits from challenge with wild type V. cholerae (Ravichandran et al., 2006).
- Host IgA response
- Description: VCUSM2 elicited high titer of anti-LPS IgG/IgA antibodies on the fourth week post-vaccination. These titers were comparable to those elicited by the wild type strain and were significantly higher than titers pre-vaccination (Ravichandran et al., 2006).
- Detailed Gene Information: Click Here.
- Host IgG Fc fragment response
- Description: VCUSM2 elicited high titer of anti-LPS IgG/IgA antibodies on the fourth week post-vaccination. These titers were comparable to those elicited by the wild type strain and were significantly higher than titers pre-vaccination (Ravichandran et al., 2006).
- Detailed Gene Information: Click Here.
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| References |
Ravichandran et al., 2006: Ravichandran M, Ali SA, Rashid NH, Kurunathan S, Yean CY, Ting LC, Bakar AS, Lalitha P, Zainuddin ZF. Construction and evaluation of a O139 Vibrio cholerae vaccine candidate based on a hemA gene mutation. Vaccine. 2006; 24(18); 3750-3761. [PubMed: 16102875].
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