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Vaccine Detail

Toxoplasma gondii mic2 mutant vaccine
Vaccine Information
  • Vaccine Name: Toxoplasma gondii mic2 mutant vaccine
  • Target Pathogen: Toxoplasma gondii
  • Target Disease: Toxoplasmosis
  • Vaccine Ontology ID: VO_0003012
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • mic2 gene engineering:
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A mic2 mutant is attenuated in mice (Huynh and Carruthers, 2006).
  • Efficacy: A mic2 mutant induces protection in mice from challenge with wild type T. gondii (Huynh and Carruthers, 2006).
  • Host Ccl2 response
    • Description: Levels of serum MCP-1 (Ccl2) were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
    • Detailed Gene Information: Click Here.
  • Host Ifng (Interferon gamma) response
    • Description: Levels of serum IFN-gamma were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
    • Detailed Gene Information: Click Here.
  • Host IL-6 response
    • Description: Levels of serum IL-6 were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
    • Detailed Gene Information: Click Here.
  • Host Il12b response
    • Description: Levels of serum IL-12p40 (IL-12b) were higher than those of uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
    • Detailed Gene Information: Click Here.
  • Host TNF-alpha response
    • Description: Levels of serum TNF-alpha were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
    • Detailed Gene Information: Click Here.
References
Huynh and Carruthers, 2006: Huynh MH, Carruthers VB. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS pathogens. 2006; 2(8); e84. [PubMed: 16933991].