• Vaccine Name: T. gondii mic2 mutant vaccine
• Target Pathogen: Toxoplasma gondii
• Target Disease: Toxoplasmosis
• Vaccine Ontology ID: VO_0003012
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• mic2 gene engineering:
  • Type: Gene mutation
  • Description: This mic2 mutant is from Toxoplasma gondii (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: A mic2 mutant is attenuated in mice (Huynh and Carruthers, 2006).
• Efficacy: A mic2 mutant induces protection in mice from challenge with wild type T. gondii (Huynh and Carruthers, 2006).
• Host Ccl2 response
  • Description: Levels of serum MCP-1 (Ccl2) were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.
• Host Ifng (Interferon gamma) response
  • Description: Levels of serum IFN-gamma were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.
• Host IL-6 response
  • Description: Levels of serum IL-6 were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.
• Host Il12b response
  • Description: Levels of serum IL-12p40 (IL-12b) were higher than those of uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.
• Host TNF-alpha response
  • Description: Levels of serum TNF-alpha were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
  • Detailed Gene Information: Click Here.