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Vaccine Detail

Toxoplasma gondii OMPDC mutant vaccine
Vaccine Information
  • Vaccine Name: Toxoplasma gondii OMPDC mutant vaccine
  • Target Pathogen: Toxoplasma gondii
  • Target Disease: Toxoplasmosis
  • Vaccine Ontology ID: VO_0003013
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • OMPDC gene engineering:
    • Type: Gene mutation
    • Description: This OMPDC mutant is from Toxoplasma gondii (Fox and Bzik, 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: An OMPDC mutant is attenuated in mice (Fox and Bzik, 2010).
  • Efficacy: An OMPDC mutant induces significant protection in mice from challenge with wild type T. gondii (Fox and Bzik, 2010).
References
Fox and Bzik, 2010: Fox BA, Bzik DJ. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infection and immunity. 2010; 78(9); 3744-3752. [PubMed: 20605980].