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Vaccine Detail

Tick-borne Encephalitis Virus C protein mutant vaccine
Vaccine Information
  • Vaccine Name: Tick-borne Encephalitis Virus C protein mutant vaccine
  • Target Pathogen: Tick-borne Encephalitis Virus (TBEV)
  • Target Disease: Tick-borne Encephalitis
  • Vaccine Ontology ID: VO_0004278
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • C protein gene engineering:
    • Type: Gene mutation
    • Description: This C protein mutant is from Tick-borne encephalitis virus (Kofler et al., 2002).
    • Detailed Gene Information: Click Here.
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Persistence: A C protein mutant is attenuated in mice (Kofler et al., 2002).
  • Efficacy: A C protein mutant induced protection in mice from challenge with wild type TBEV (Kofler et al., 2002).
References
Kofler et al., 2002: Kofler RM, Heinz FX, Mandl CW. Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence. Journal of virology. 2002; 76(7); 3534-3543. [PubMed: 11884577].