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Vaccine Detail

Streptococcus equi vicK mutant vaccine
Vaccine Information
  • Vaccine Name: Streptococcus equi vicK mutant vaccine
  • Target Pathogen: Streptococcus equi
  • Target Disease: Strangles (also equine distemper)
  • Vaccine Ontology ID: VO_0002798
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • vicK gene engineering:
    • Type: Gene mutation
    • Description: This vicK mutant is from Streptococcus equi (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: A vicK mutant is attenuated in mice (Liu et al., 2008).
  • Efficacy: A vicK mutant induces protection in mice from challenge with wild type S. equi (Liu et al., 2008).
References
Liu et al., 2008: Liu M, McClure MJ, Zhu H, Xie G, Lei B. The Two-Component Regulatory System VicRK is Important to Virulence of Streptococcus equi Subspecies equi. The open microbiology journal. 2008; 2; 89-93. [PubMed: 19088917].