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Vaccine Detail

Staphylococcus aureus aroA mutant vaccine
Vaccine Information
  • Vaccine Name: Staphylococcus aureus aroA mutant vaccine
  • Target Pathogen: Staphylococcus aureus
  • Target Disease: Staph infections
  • Vaccine Ontology ID: VO_0002797
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • aroA gene engineering:
    • Type: Gene mutation
    • Description: This aroA mutant is from Staphylococcus aureus (Buzzola et al., 2006).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramammary immunization
Host Response

Mouse Response

  • Persistence: An aroA mutant is attenuated in mice (Buzzola et al., 2006).
  • Efficacy: An aroA mutant induces significant protection in mice from challenge with wild type S. aureus (Buzzola et al., 2006).
  • Host Ifng (Interferon gamma) response
    • Description: Ninety-six hours after challenge with the wild-type strain RN6390 or heterologous strain MB319, the relative mRNA levels of IFN-γ and IL-4 were determined in mammary glands by RT-PCR. Mammary glands from mice immunized with the aroA mutant showed a significant increase in the level of IFN-γ transcripts compared with control, unvaccinated mice (Buzzola et al., 2006).
    • Detailed Gene Information: Click Here.
  • Host Il4 (interleukin 4) response
    • Description: Ninety-six hours after challenge with the wild-type strain RN6390 or heterologous strain MB319, the relative mRNA levels of IFN-γ and IL-4 were determined in mammary glands by RT-PCR. Mice immunized with the aroA mutant showed a significant increase in the level of IL-4 transcripts compared with control, unvaccinated mice (Buzzola et al., 2006).
    • Detailed Gene Information: Click Here.
References
Buzzola et al., 2006: Buzzola FR, Barbagelata MS, Caccuri RL, Sordelli DO. Attenuation and persistence of and ability to induce protective immunity to a Staphylococcus aureus aroA mutant in mice. Infection and immunity. 2006; 74(6); 3498-3506. [PubMed: 16714581].