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Vaccine Detail
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Simian Immunodeficiency Virus nef mutant vaccine |
| Vaccine Information |
- Vaccine Name: Simian Immunodeficiency Virus nef mutant vaccine
- Target Pathogen: Simian Immunodeficiency Virus
- Target Disease: Simian AIDS
- Vaccine Ontology ID: VO_0002994
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rhesus monkey
- nef
gene engineering:
- Type: Gene mutation
- Description: This nef mutant is from Simian Immunodeficiency Virus (Daniel et al., 1992).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Monkey Response
- Persistence: A nef mutant is attenuated in rhesus monkeys (Daniel et al., 1992).
- Efficacy: A nef mutant induces protection in rhesus monkeys from challenge with wild type SIV (Daniel et al., 1992).
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| References |
Daniel et al., 1992: Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science (New York, N.Y.). 1992; 258(5090); 1938-1941. [PubMed: 1470917].
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