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Vaccine Detail
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Shigella flexneri aroD mutant vaccine |
| Vaccine Information |
- Vaccine Name: Shigella flexneri aroD mutant vaccine
- Target Pathogen: Shigella
- Target Disease: Shigellosis
- Vaccine Ontology ID: VO_0002923
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Monkey
- AroD
gene engineering:
- Type: Gene mutation
- Description: This aroD mutant is from Shigella flexneri (Kärnell et al., 1993).
- Detailed Gene Information: Click Here.
- Immunization Route: Oral immunization
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| Host Response |
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Monkey Response
- Persistence: An aroD mutant is highly attenuated in monkeys (Kärnell et al., 1993).
- Efficacy: An aroD mutant induces significant protection in monkeys from challenge with wild type S. flexneri (Kärnell et al., 1993).
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| References |
Kärnell et al., 1993: Kärnell A, Cam PD, Verma N, Lindberg AA. AroD deletion attenuates Shigella flexneri strain 2457T and makes it a safe and efficacious oral vaccine in monkeys. Vaccine. 1993; 11(8); 830-836. [PubMed: 8356844].
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