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Vaccine Detail
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Shigella flexneri envZ mutant vaccine |
| Vaccine Information |
- Vaccine Name: Shigella flexneri envZ mutant vaccine
- Target Pathogen: Shigella
- Target Disease: Shigellosis
- Product Name: SC433
- Vaccine Ontology ID: VO_0002924
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque monkey
- envZ
gene engineering:
- Type: Gene mutation
- Description: This envZ mutant is from Shigella flexneri (Sansonetti et al., 1991).
- Detailed Gene Information: Click Here.
- Immunization Route: Intragastric immunization
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| Host Response |
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Macaque Response
- Persistence: An envZ mutant (SC433) is greatly decreased in virulence in macaque monkeys, though some mild clinical signs were still recorded (Sansonetti et al., 1991).
- Efficacy: An envZ mutant is highly protective in macaque monkeys against a challenge of wild type S. flexneri delivered 1 month after inoculation (Sansonetti et al., 1991).
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| References |
Sansonetti et al., 1991: Sansonetti PJ, Arondel J, Fontaine A, d'Hauteville H, Bernardini ML. OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis. Vaccine. 1991; 9(6); 416-422. [PubMed: 1887672].
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