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Vaccine Detail

Salmonella typhi aroA mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella typhi aroA mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002863
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • aroA gene engineering:
    • Type: Gene mutation
    • Description: This aroA was mutated from Salmonella typhi strain Ty2 (Dougan et al., 1987).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: An aroA mutant is attenuated in mice (Dougan et al., 1987).
  • Efficacy: An aroA mutant induced significant protection in mice from challenge with wild type S. typhi Ty2 (Dougan et al., 1987).
References
Dougan et al., 1987: Dougan G, Maskell D, Pickard D, Hormaeche C. Isolation of stable aroA mutants of Salmonella typhi Ty2: properties and preliminary characterisation in mice. Molecular & general genetics : MGG. 1987; 207(2-3); 402-405. [PubMed: 3039297].