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Vaccine Detail

Salmonella Typhimurium asd mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium asd mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002867
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • asd gene engineering:
    • Type: Gene mutation
    • Description: This asd mutant is from Salmonella Typhimurium (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: An asd mutant is attenuated in mice (Piao et al., 2010).
  • Efficacy: An asd mutant induces significant protection in mice from challenge with wild type Salmonella typhimurium (Piao et al., 2010).
  • Host IgA response
    • Description: Immunizing twice elicited significantly higher levels of IgA than immunizing once, and oral immunization was the most effective route in comparison to i.p. immunization. IgA levels for both oral and i.p. routes were significantly higher than unimmunized control mice titers. Sera was obtained two weeks after immunization (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host IgG response
    • Description: Immunizing twice instead of once induced significantly higher levels of IgG via the oral route compared to non-immunized mice. Sera was obtained 2 weeks after immunization. I.p. immunization induced higher levels of IgG antibodies than oral immunization (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host Ighg1 response
    • Description: Immunizing twice instead of once induced significantly higher levels of IgG1 via the oral route compared to non-immunized mice. Sera was obtained 2 weeks after immunization. I.p. immunization induced higher levels of IgG1 antibodies than oral immunization (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host Ighv1-9 response
    • Description: Immunizing twice instead of once induced significantly higher levels of IgG2a via the oral route compared to non-immunized mice. Sera was obtained 2 weeks after immunization. I.p. immunization induced higher levels of IgG2a antibodies than oral immunization (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host IL-17 response
    • Description: Splenocytes from mice immunized via the oral route showed significantly high levels of IL-17 compared to non-immunized mice. Splenocytes were isolated and stimulated in vitro for 24 hours with wild type S. Typhimurium lysate. Immunizing twice was more effective than immunizing once (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
References
Piao et al., 2010: Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. Journal of microbiology (Seoul, Korea). 2010; 48(4); 486-495. [PubMed: 20799091].