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Vaccine Detail

Salmonella Typhimurium clpP mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium clpP mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Product Name: CS2007
  • Vaccine Ontology ID: VO_0002872
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This clpP mutant is from Salmonella Typhimurium (Matsui et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: A clpP mutant (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice (Matsui et al., 2003).
  • Efficacy: A clpP mutant elicited protection in mice from challenge with wild type S. typhimurium (Matsui et al., 2003).
  • Host IgA response
    • Description: Significant increases of lipopolysaccharide-specific immunoglobulin G (IgG) and secretory IgA were detected at week 4 and maintained until at least week 12 after inoculation in serum and bile. Testing before week 4 revealed undetectable or extremely low levels of antibodies, meaning the presence of much higher levels after week 4 were the result of upregulation of IgG and IgA (Matsui et al., 2003).
    • Detailed Gene Information: Click Here.
  • Host IgG response
    • Description: Significant increases of lipopolysaccharide-specific immunoglobulin G (IgG) and secretory IgA were detected at week 4 and maintained until at least week 12 after inoculation in serum and bile. Testing before week 4 revealed undetectable or extremely low levels of antibodies, meaning the presence of much higher levels after week 4 were the result of upregulation of IgG and IgA (Matsui et al., 2003).
    • Detailed Gene Information: Click Here.
References
Matsui et al., 2003: Matsui H, Suzuki M, Isshiki Y, Kodama C, Eguchi M, Kikuchi Y, Motokawa K, Takaya A, Tomoyasu T, Yamamoto T. Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium. Infection and immunity. 2003; 71(1); 30-39. [PubMed: 12496146].