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Vaccine Detail

Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pigs
  • cpxA gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • gyrA gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • rpoB gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Pig Response

  • Persistence: A gyrA/cpxA/rpoB mutant was attenuated in pigs (Roesler et al., 2004).
  • Efficacy: A gyrA/cpxA/rpoB mutant protected pigs against challenge with wild type Salmonella Typhimurium (Roesler et al., 2004).
  • Host IgM response
    • Description: A significant discrimination between vaccinated and non-vaccinated pigs was observed when IgM was measured after challenge, but here, the non-immunized animals had an elevated humoral antibody response after challenge with wild type Salmonella. The first significant difference was seen on day 35 after vaccination (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
References
Roesler et al., 2004: Roesler U, Marg H, Schröder I, Mauer S, Arnold T, Lehmann J, Truyen U, Hensel A. Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant. Vaccine. 2004; 23(5); 595-603. [PubMed: 15542179].