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Vaccine Detail

Salmonella enterica fliC/guaB mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella enterica fliC/guaB mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, chicken
  • fliC gene engineering:
    • Type: Gene mutation
    • Description: This fliC/guaB mutant is from Salmonella enterica (Adriaensen et al., 2007).
    • Detailed Gene Information: Click Here.
  • guaB from S. enteritidis str. P125109 gene engineering:
    • Type: Gene mutation
    • Description: This fliC/guaB mutant is from Salmonella enterica (Adriaensen et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Persistence: A fliC/guaB mutant is attenuated in mice (Adriaensen et al., 2007).
  • Efficacy: A fliC/guaB mutant induces significant protection in mice from challenge with wild type S. enterica (Adriaensen et al., 2007).
  • Host IgG response
    • Description: Fifty-four days following initial oral immunization of BALB/c mice with approximately 108 CFU per mouse of, respectively, the S. enterica serovar Enteritidis ΔguaB and S. enterica serovar Enteritidis ΔguaB ΔfliC mutants, blood samples were collected from the tail arteries of five mice. Comparison between sera of mice immunized with S. enterica serovar Enteritidis ΔguaB and mice immunized with S. enterica serovar Enteritidis ΔguaB ΔfliC showed that, in both cases, comparable anti-LPS serum IgG responses were elicited (Adriaensen et al., 2007).
    • Detailed Gene Information: Click Here.

Chicken Response

References
Adriaensen et al., 2007: Adriaensen C, De Greve H, Tian JQ, De Craeye S, Gubbels E, Eeckhaut V, Van Immerseel F, Ducatelle R, Kumar M, Hernalsteens JP. A live Salmonella enterica serovar Enteritidis vaccine allows serological differentiation between vaccinated and infected animals. Infection and immunity. 2007; 75(5); 2461-2468. [PubMed: 17261603].