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Vaccine Detail

Salmonella Typhimurium IppA/IppB/msbB
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium IppA/IppB/msbB
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • lppA gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • lppB gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • msbB gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: An IppA/IppB/msbB mutant is attenuated in mice (Liu et al., 2008).
  • Efficacy: An IppA/IppB/msbB mutant provides significant protection in mice from challenge with wild type S. Typhimurium (Liu et al., 2008).
  • Host Ighg1 response
    • Description: This mutant elicited a significantly greater serum IgG1 response compared to infection with the wild type on days 2, 5, and 7 post infection. Peak levels were reached five days after infection (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • Host IL-6 response
    • Description: Culture supernatants from T cells infected with the lppB/msbB mutant contained significantly higher levels of IL-6 than did supernatants from T cells that were infected with WT S. Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
References
Liu et al., 2008: Liu T, K├Ânig R, Sha J, Agar SL, Tseng CT, Klimpel GR, Chopra AK. Immunological responses against Salmonella enterica serovar Typhimurium Braun lipoprotein and lipid A mutant strains in Swiss-Webster mice: potential use as live-attenuated vaccines. Microbial pathogenesis. 2008; 44(3); 224-237. [PubMed: 17997275].