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Vaccine Detail

Salmonella Typhimurium ompR mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium ompR mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002902
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • ompR gene engineering:
    • Type: Gene mutation
    • Description: This ompR mutant is from Salmonella Typhimurium (Dorman et al., 1989).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
Host Response

Mouse Response

  • Persistence: An ompR mutant is attenuated in mice after oral challenge (Dorman et al., 1989).
  • Efficacy: A ompR mutant conferred significant protection in mice from challenge with wild type Salmonella Typhimurium (Dorman et al., 1989).
References
Dorman et al., 1989: Dorman CJ, Chatfield S, Higgins CF, Hayward C, Dougan G. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infection and immunity. 1989; 57(7); 2136-2140. [PubMed: 2543631].