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Vaccine Detail

Salmonella Typhi phoP mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhi phoP mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002903
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • PhoP gene engineering:
    • Type: Gene mutation
    • Description: This phoP mutant is from Salmonella Typhi (Lee et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A phoP mutant is attenuated in mice (Lee et al., 2007).
  • Efficacy: A phoP mutant provides significant protection in mice from challenge with wild type S. Typhi (Lee et al., 2007).
  • Host IgG response
    • Description: The serum titer of IgG was more than 1000-fold higher in mice immunized with a phoP mutant than in control mice. The mutant induced high titers of serum IgG against lipopolysaccharide of S. typhi at 8 weeks in the immunization schedule (Lee et al., 2007).
    • Detailed Gene Information: Click Here.
  • Host IgG2b response
    • Description: The titers of serum IgG2b increased significantly 8 weeks after inoculation in mice immunized with a phoP mutant as compared to unimmunized control mice (Lee et al., 2007).
    • Detailed Gene Information: Click Here.
  • Host Ighv1-9 response
    • Description: Titers of serum IgG2a increased significantly 8 weeks after inoculation in mice immunized with a phoP mutant as compared to unimmunized control mice (Lee et al., 2007).
    • Detailed Gene Information: Click Here.
References
Lee et al., 2007: Lee HY, Cho SA, Lee IS, Park JH, Seok SH, Baek MW, Kim DJ, Lee SH, Hur SJ, Ban SJ, Lee YK, Han YK, Cho YK, Park JH. Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice. FEMS immunology and medical microbiology. 2007; 51(2); 310-318. [PubMed: 17725620].