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Vaccine Detail

Salmonella Typhimurium poxA mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium poxA mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002904
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • poxA gene engineering:
    • Type: Gene mutation
    • Description: This poxA mutant is from Salmonella Typhimurium (Kaniga et al., 1998).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A poxA mutant is attenuated in mice (Kaniga et al., 1998).
  • Efficacy: A poxA mutant provided significant protection in mice from challenge with wild type Salmonella Typhimurium (Kaniga et al., 1998).
  • Host IgA response
    • Description: Sera were collected 29 days after a single oral immunization and 16 days post challenge. High IgG, IgA, and, to a lesser extent, IgM titers were detected in orally immunized animals, indicating that the ΔpoxA270 mutant derivative of S. typhimurium was very immunogenic in mice. This was more than negative control serum collected from non immunized mice (Kaniga et al., 1998).
    • Detailed Gene Information: Click Here.
  • Host IgG response
    • Description: Sera were collected 29 days after a single oral immunization and 16 days post challenge. High IgG, IgA, and, to a lesser extent, IgM titers were detected in orally immunized animals, indicating that the ΔpoxA270 mutant derivative of S. typhimurium was very immunogenic in mice. This was significantly more than negative control serum collected from non immunized mice (Kaniga et al., 1998).
    • Detailed Gene Information: Click Here.
References
Kaniga et al., 1998: Kaniga K, Compton MS, Curtiss R 3rd, Sundaram P. Molecular and functional characterization of Salmonella enterica serovar typhimurium poxA gene: effect on attenuation of virulence and protection. Infection and immunity. 1998; 66(12); 5599-5606. [PubMed: 9826331].