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Vaccine Detail

Salmonella Typhimurium rpoS mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium rpoS mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002908
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • rpoS gene engineering:
    • Type: Gene mutation
    • Description: This rpoS mutant is from Salmonella Typhimurium (Coynault et al., 1996).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: An rpoS mutant is attenuated in mice (Coynault et al., 1996).
  • Efficacy: An rpoS mutant protects mice from challenge with wild type Salmonella typhimurium after a single dose (Coynault et al., 1996).
References
Coynault et al., 1996: Coynault C, Robbe-Saule V, Norel F. Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon. Molecular microbiology. 1996; 22(1); 149-160. [PubMed: 8899717].