VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

Salmonella Typhimurium ruvB mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium ruvB mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002909
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • ruvB gene engineering:
    • Type: Gene mutation
    • Description: This ruvB mutant is from Salmonella Typhimurium (Choi et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A ruvB mutant is attenuated in mice (Choi et al., 2010).
  • Efficacy: A ruvB mutant provides protection in mice from challenge with wild type Salmonella Typhimurium (Choi et al., 2010).
  • Host Ifng (Interferon gamma) response
    • Description: The vaccine induced significant production of IFN-γ on days 18 and 22 after vaccination while the control mice (non vaccinated) showed no change in the level of IFN-γ (Choi et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host IgG response
    • Description: Total IgG levels were significantly increased in vaccinated mice compared to the non-vaccinated group at both day 18 and day 22 (Choi et al., 2010).
    • Detailed Gene Information: Click Here.
References
Choi et al., 2010: Choi J, Shin D, Ryu S. Salmonella enterica serovar Typhimurium ruvB mutant can confer protection against salmonellosis in mice. Vaccine. 2010; 28(39); 6436-6444. [PubMed: 20670908].