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Vaccine Detail

Salmonella Typhimurium trxA mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium trxA mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002913
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • trxA gene engineering:
    • Type: Gene mutation
    • Description: A trxA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium (Peters et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
Host Response

Mouse Response

  • Persistence: A trxA mutant is attenuated in mice (Peters et al., 2010).
  • Efficacy: A trxA mutant induces protection in mice from challenge with wild type Salmonella Typhimurium (Peters et al., 2010).
References
Peters et al., 2010: Peters SE, Paterson GK, Bandularatne ES, Northen HC, Pleasance S, Willers C, Wang J, Foote AK, Constantino-Casas F, Scase TJ, Blacklaws BA, Bryant CE, Mastroeni P, Charles IG, Maskell DJ. Salmonella enterica serovar typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261. Infection and immunity. 2010; 78(1); 326-336. [PubMed: 19884329].