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Vaccine Detail

Pseudorabies virus UL50 mutant vaccine
Vaccine Information
  • Vaccine Name: Pseudorabies virus UL50 mutant vaccine
  • Target Pathogen: Pseudorabies virus
  • Target Disease: Aujeszky's disease
  • Vaccine Ontology ID: VO_0002989
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • UL50 gene engineering:
    • Type: Gene mutation
    • Description: This UL50 mutant is from Suid herpesvirus 1 (Jöns et al., 1997).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Pig Response

  • Persistence: A UL50 mutant is attenuated in pigs (Jöns et al., 1997).
  • Efficacy: A UL50 mutant induces protection in pigs from challenge with wild type Pseudorabies virus (Jöns et al., 1997).
References
Jöns et al., 1997: Jöns A, Gerdts V, Lange E, Kaden V, Mettenleiter TC. Attenuation of dUTPase-deficient pseudorabies virus for the natural host. Veterinary microbiology. 1997; 56(1-2); 47-54. [PubMed: 9228681].