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Vaccine Detail

Pseudorabies virus US3 mutant vaccine
Vaccine Information
  • Vaccine Name: Pseudorabies virus US3 mutant vaccine
  • Target Pathogen: Pseudorabies virus
  • Target Disease: Aujeszky's disease
  • Vaccine Ontology ID: VO_0002990
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • US3 gene engineering:
    • Type: Gene mutation
    • Description: This US3 mutant is from Suid herpesvirus 1 (Kimman et al., 1994).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Pig Response

  • Persistence: A US3 mutant is attenuated in pigs (Kimman et al., 1994).
  • Efficacy: A US3 mutant induces complete protection in pigs from challenge with wild type Pseudorabies virus (Kimman et al., 1994).
References
Kimman et al., 1994: Kimman TG, De Wind N, De Bruin T, de Visser Y, Voermans J. Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity. Virology. 1994; 205(2); 511-518. [PubMed: 7975253].