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Vaccine Detail
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P. yoelii UIS3 mutant vaccine |
| Vaccine Information |
- Vaccine Name: P. yoelii UIS3 mutant vaccine
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Vaccine Ontology ID: VO_0003011
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: UIS3(Tarun et al., 2007)
- UIS3
gene engineering:
- Type: Gene mutation
- Description: This UIS3 mutant is from Plasmodium yoelii (Tarun et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Persistence: A UIS3 mutant is attenuated in mice (Tarun et al., 2007).
- Efficacy: A UIS3 mutant provided complete protection in mice after two doses from challenge with wild type Plasmodium yoelii (Tarun et al., 2007).
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| References |
Tarun et al., 2007: Tarun AS, Dumpit RF, Camargo N, Labaied M, Liu P, Takagi A, Wang R, Kappe SH. Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. The Journal of infectious diseases. 2007; 196(4); 608-616. [PubMed: 17624848].
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