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Vaccine Detail

Neisseria meningitidis rfaF/siaD mutant vaccine
Vaccine Information
  • Vaccine Name: Neisseria meningitidis rfaF/siaD mutant vaccine
  • Target Pathogen: Neisseria meningitidis
  • Target Disease: Meningitis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • rfaF gene engineering:
    • Type: Gene mutation
    • Description: This rfaF/siaD mutant is from Neisseria meningitidis (Li et al., 2004).
    • Detailed Gene Information: Click Here.
  • siaD gene engineering:
    • Type: Gene mutation
    • Description: This rfaF/siaD mutant is from Neisseria meningitidis (Li et al., 2004).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A rfaF/siaD mutant is attenuated in mice (Li et al., 2004).
  • Efficacy: An rfaF/siaD mutant induces significant protection in mice from challenge with wild type Neisseria meningitidis (Li et al., 2004).
References
Li et al., 2004: Li Y, Sun YH, Ison C, Levine MM, Tang CM. Vaccination with attenuated Neisseria meningitidis strains protects against challenge with live Meningococci. Infection and immunity. 2004; 72(1); 345-351. [PubMed: 14688114].