|
Vaccine Detail
Mycoplasma gallisepticum lpd mutant vaccine |
Vaccine Information |
- Vaccine Name: Mycoplasma gallisepticum lpd mutant vaccine
- Target Pathogen: Mycoplasma gallisepticum
- Target Disease: Chronic respiratory disease
- Vaccine Ontology ID: VO_0002857
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- lpd
gene engineering:
- Type: Gene mutation
- Description: This lpd mutant is from Mycoplasma gallisepticum (Gates et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intratracheal immunization
|
Host Response |
Chicken Response
- Persistence: An lpd mutant is highly attenuated in chickens (Gates et al., 2008).
- Efficacy: An lpd mutant induces significant protection in chickens from challenge with wild type Mycoplasma gallisepticum (Gates et al., 2008).
- Host IgG Fc fragment response
- Description: Mg 7 vaccinated chickens mounted a strong humoral anti-M. gallisepticum-specific IgG response that was sustained for at least 4 weeks post-exposure. M. gallisepticum-specific immunoglobulin responses were detected in chickens inoculated with either Mg 7 or R(low) but not in chickens that received 1× PBS alone. The level of M. gallisepticum-specific serum IgG was highest in the R(low) treated animals at both the 2- and 4-week time points, however, the Mg 7 inoculated birds mounted a fairly robust response considering its level of attenuation. Thus, the Mg 7 vaccine induced significantly higher IgG responses than PBS inoculated chickens, but significantly lower than those inoculated with wild type R(low) (Gates et al., 2008).
- Detailed Gene Information: Click Here.
|
References |
Gates et al., 2008: Gates AE, Frasca S, Nyaoke A, Gorton TS, Silbart LK, Geary SJ. Comparative assessment of a metabolically attenuated Mycoplasma gallisepticum mutant as a live vaccine for the prevention of avian respiratory mycoplasmosis. Vaccine. 2008; 26(16); 2010-2019. [PubMed: 18342996].
|
|