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Vaccine Detail

Mycobacterium tuberculosis fadD26 mutant vaccine
Vaccine Information
  • Vaccine Name: Mycobacterium tuberculosis fadD26 mutant vaccine
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Vaccine Ontology ID: VO_0002781
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • fadD26 gene engineering:
    • Type: Gene mutation
    • Description: This fadD26 mutant is from Mycobacterium tuberculosis (Infante et al., 2005).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intratracheal immunization
Host Response

Mouse Response

  • Persistence: A fadD26 mutant is attenuated in mice (Infante et al., 2005).
  • Efficacy: A fadD26 mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Infante et al., 2005).
  • Host Ifng (Interferon gamma) response
    • Description: The fadD26 mutant induced a progressive increase in IFN-γ expression in lung homogenates of mice, peaking at day 60, and 2 months later it had decreased by only 20% from its maximal level. However, it induced significantly lower expression than that induced by the wild type pathogen (MT-103) from days 1-21 post infection (Infante et al., 2005).
    • Detailed Gene Information: Click Here.
  • Host Il4 (interleukin 4) response
    • Description: A fadD26 mutant induced a significantly lower and stable IL-4 expression as compared to the wild type (MT103) during the first month of infection in mice, followed by an increase of 50% at days 60 and 120. IL-4 levels of a fadD26 mutant-vaccinated mice were significantly lower than those infected with the wild type on days 3, 7, 21, 28, and 60 post infection in lung homogenates (Infante et al., 2005).
    • Detailed Gene Information: Click Here.
  • Host Nos2 response
    • Description: Mice infected with the fadD26 mutant showed significant higher iNOS expression than the parent strain in lung homogenates days 21, 28 and 60 post infection. Results showed that the fadD26 mutant is also more efficient than its parental strain at inducing iNOS expression (Infante et al., 2005).
    • Detailed Gene Information: Click Here.
  • Host TNF-alpha response
    • Description: The fadD26 mutant induced stable TNF-α expression in mice, significantly lower than that induced by MT-103 (WT strain) after 1 week of infection. In lung homogenates, fadD26 mutant vaccination induced significantly lower TNF-alpha levels on days 7, 14, 28, and 60 as compared to mice vaccinated with the wild type (Infante et al., 2005).
    • Detailed Gene Information: Click Here.
  • Information about this animal model: Mouse Model for TB research
References
Infante et al., 2005: Infante E, Aguilar LD, Gicquel B, Pando RH. Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant. Clinical and experimental immunology. 2005; 141(1); 21-28. [PubMed: 15958066].