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Vaccine Detail

Mycobacterium tuberculosis mce-2 mutant vaccine
Vaccine Information
  • Vaccine Name: Mycobacterium tuberculosis mce-2 mutant vaccine
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Vaccine Ontology ID: VO_0004279
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • mce-2 gene engineering:
    • Type: Gene mutation
    • Description: This mce-2 mutant is from Mycobacterium tuberculosis (Aguilar et al., 2006).
    • Detailed Gene Information: Click Here.
  • mce-3 gene engineering:
    • Type: Gene mutation
    • Description: This mce-2/mce-3 mutant is from Mycobacterium tuberculosis (Aguilar et al., 2006).
    • Detailed Gene Information: Click Here.
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Persistence: A mce-2 mutant is attenuated in mice (Aguilar et al., 2006).
  • Efficacy: A mce-2 mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Aguilar et al., 2006).
  • Host Ifng (Interferon gamma) response
    • Description: Mutant mce-2 induced a lower but progressive expression of IFN-γ than the parent strain in mice, peaking at day 120 post-infection. The IFN-gamma response in lungs was significantly lower in mice immunized with mce-2 mutants on days 1, 3, 7, 14, and 21 days post infection as compared to mice infected with the wild type (Aguilar et al., 2006).
    • Detailed Gene Information: Click Here.
  • Host Il4 (interleukin 4) response
    • Description: The mce-2 mutant maintained low IL-4 expression until day 60 post-infection, showing slight increase at day 120. The expression of IL-4 was higher in the lungs of mice infected with the parental strain. Infection with the wild type strain induced significantly more IL-4 than that induced by immunization with the mutant on days 21, 28, and 60 post infection (Aguilar et al., 2006).
    • Detailed Gene Information: Click Here.
  • Information about this animal model: Mouse Model for TB research
References
Aguilar et al., 2006: Aguilar LD, Infante E, Bianco MV, Cataldi A, Bigi F, Pando RH. Immunogenicity and protection induced by Mycobacterium tuberculosis mce-2 and mce-3 mutants in a Balb/c mouse model of progressive pulmonary tuberculosis. Vaccine. 2006; 24(13); 2333-2342. [PubMed: 16388878].