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Vaccine Detail

Mycobacterium tuberculosis proC mutant vaccine

Vaccine Information

Vaccine Name: Mycobacterium tuberculosis proC mutant vaccine
Target Pathogen: Mycobacterium tuberculosis
Target Disease: Tuberculosis
Vaccine Ontology ID: VO_0002791
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
proC gene engineering:
- Type: Gene mutation
- Description: This proC mutant is from Mycobacterium tuberculosis (Smith et al., 2001).
- Detailed Gene Information: Click Here.
Immunization Route: Intravenous injection (i.v.)

Host Response

Mouse Response

Persistence: A proC mutant is attenuated in mice (Smith et al., 2001).
Efficacy: A proC mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Smith et al., 2001).
Information about this animal model: Mouse Model for TB research

References

Smith et al., 2001: Smith DA, Parish T, Stoker NG, Bancroft GJ. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infection and immunity. 2001; 69(2); 1142-1150. [PubMed: 11160012].