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Vaccine Detail

Infectious Hematopoietic Necrosis Virus NV mutant vaccine

Vaccine Information

Vaccine Name: Infectious Hematopoietic Necrosis Virus NV mutant vaccine
Target Pathogen: Infectious Hematopoietic Necrosis Virus
Target Disease: Infectious hematopoietic necrosis
Vaccine Ontology ID: VO_0002979
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Rainbow trout
NV gene engineering:
- Type: Gene mutation
- Description: This NV mutant is from Infectious hematopoietic necrosis virus (Thoulouze et al., 2004).
- Detailed Gene Information: Click Here.
Immunization Route: Intraperitoneal injection (i.p.)

Host Response

Rainbow trout Response

Persistence: A NV mutant is attenuated in rainbow trout (Thoulouze et al., 2004).
Efficacy: An NV mutant induces significant protection in rainbow trout from challenge with wild type IHNV (Thoulouze et al., 2004).

References

Thoulouze et al., 2004: Thoulouze MI, Bouguyon E, Carpentier C, Brémont M. Essential role of the NV protein of Novirhabdovirus for pathogenicity in rainbow trout. Journal of virology. 2004; 78(8); 4098-4107. [PubMed: 15047826].