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Vaccine Detail

Human metapneumovirus G protein mutant vaccine
Vaccine Information
  • Vaccine Name: Human metapneumovirus G protein mutant vaccine
  • Target Pathogen: Human metapneumovirus
  • Target Disease: Respiratory tract infection
  • Vaccine Ontology ID: VO_0002976
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: African green monkey
  • G protein gene engineering:
    • Type: Gene mutation
    • Description: This G protein is from Human metapneumovirus (Biacchesi et al., 2005).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Monkey Response

  • Persistence: A G protein mutant is attenuated in African green monkeys (Biacchesi et al., 2005).
  • Efficacy: A G protein mutant induces significant protection in African green monkeys from challenge with wild type HMPV (Biacchesi et al., 2005).
References
Biacchesi et al., 2005: Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Journal of virology. 2005; 79(19); 12608-12613. [PubMed: 16160190].