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Vaccine Detail

Herpes simplex virus 1 gD mutant vaccine

Vaccine Information

Vaccine Name: Herpes simplex virus 1 gD mutant vaccine
Target Pathogen: Herpes simplex virus type 1 and 2
Target Disease: Herpes
Product Name: KOS-gDA3C
Vaccine Ontology ID: VO_0002970
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
gD gene engineering:
- Type: Gene mutation
- Description: This gD mutant is from human herpesvirus 1 (Awasthi et al., 2008).
- Detailed Gene Information: Click Here.
Immunization Route: Flank scratch

Host Response

Mouse Response

Persistence: A gD mutant is attenuated in mice (Awasthi et al., 2008).
Efficacy: A gD mutant induces significant protection in mice from challenge with wild type HSV-1 (Awasthi et al., 2008).

References

Awasthi et al., 2008: Awasthi S, Lubinski JM, Eisenberg RJ, Cohen GH, Friedman HM. An HSV-1 gD mutant virus as an entry-impaired live virus vaccine. Vaccine. 2008; 26(9); 1195-1203. [PubMed: 18243431].