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Vaccine Detail

Herpes simplex virus 1 UL29 mutant vaccine

Vaccine Information

Vaccine Name: Herpes simplex virus 1 UL29 mutant vaccine
Target Pathogen: Herpes simplex virus type 1 and 2
Target Disease: Herpes
Vaccine Ontology ID: VO_0002974
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
UL29 gene engineering:
- Type: Gene mutation
- Description: This UL29 mutant is from human herpesvirus type 1 (Morrison and Knipe, 1994).
- Detailed Gene Information: Click Here.
Immunization Route: subcutaneous injection

Host Response

Mouse Response

Persistence: A UL29 mutant is attenuated in mice (Morrison and Knipe, 1994).
Efficacy: A UL29 mutant induces significant protection from challenge with wild type HSV-1 (Morrison and Knipe, 1994).

References

Morrison and Knipe, 1994: Morrison LA, Knipe DM. Immunization with replication-defective mutants of herpes simplex virus type 1: sites of immune intervention in pathogenesis of challenge virus infection. Journal of virology. 1994; 68(2); 689-696. [PubMed: 8289372].