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Vaccine Detail

Francisella tularensis capB mutant vaccine
Vaccine Information
  • Vaccine Name: Francisella tularensis capB mutant vaccine
  • Target Pathogen: Francisella tularensis
  • Target Disease: Tularemia
  • Vaccine Ontology ID: VO_0002840
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • capB gene engineering:
    • Type: Gene mutation
    • Description: This capB mutant is from Francisella tularensis (Jia et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: A capB mutant is attenuated in mice (Jia et al., 2010).
  • Efficacy: A capB mutant induces significant protection in mice from challenge with wild type F. tularensis (Jia et al., 2010).
  • Host IgG response
    • Description: Following i.n. immunization, LVS ΔcapB induced significantly higher levels of serum IgG, IgG2a, and IgM antibodies in mice than LVS by 7 days post immunization (Jia et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host Ighv1-9 response
    • Description: Following i.n. immunization, LVS ΔcapB induced significantly higher levels of serum IgG, IgG2a, and IgM antibodies in mice than LVS by 7 days post immunization (Jia et al., 2010).
    • Detailed Gene Information: Click Here.
  • Host IgM response
    • Description: Following i.n. immunization, LVS ΔcapB induced significantly higher levels of serum IgG, IgG2a, and IgM antibodies in mice than LVS by 7 days post immunization (Jia et al., 2010).
    • Detailed Gene Information: Click Here.
References
Jia et al., 2010: Jia Q, Lee BY, Bowen R, Dillon BJ, Som SM, Horwitz MA. A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge. Infection and immunity. 2010; 78(10); 4341-4355. [PubMed: 20643859].