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Vaccine Detail
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Francisella tularensis FTL0552 mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis FTL0552 mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Vaccine Ontology ID: VO_0002842
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FTL0552
gene engineering:
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Persistence: A FTL0552 mutant is attenuated in mice (Sammons-Jackson et al., 2008).
- Efficacy: A FTL0552 mutant provided partial protection in mice from challenge with wild type Francisella tularensis SchuS4 (Sammons-Jackson et al., 2008).
- Host Ccl2 response
- Description: LVS induced a significantly higher MCP-1 (Ccl2) response in mice lung homogenates as compared to FTL0552 mice beginning day 3 after infection (Sammons-Jackson et al., 2008).
- Detailed Gene Information: Click Here.
- Host Ifng (Interferon gamma) response
- Description: LVS induced a significantly higher IFN-gamma response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
- Detailed Gene Information: Click Here.
- Host IL-6 response
- Description: LVS induced a significantly higher IL-6 response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
- Detailed Gene Information: Click Here.
- Host Il12b response
- Description: An FTL0552 mutant induced significantly elevated levels of IL-12 in C57BL/6 mice lung homogenates by day 7 post infection compared to LVS (Sammons-Jackson et al., 2008).
- Detailed Gene Information: Click Here.
- Host TNF-alpha response
- Description: LVS induced a significantly higher TNF-alpha response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
- Detailed Gene Information: Click Here.
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| References |
Sammons-Jackson et al., 2008: Sammons-Jackson WL, McClelland K, Manch-Citron JN, Metzger DW, Bakshi CS, Garcia E, Rasley A, Anderson BE. Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS). DNA and cell biology. 2008; 27(7); 387-403. [PubMed: 18613792].
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