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Vaccine Detail

Francisella tularensis FTL0552 mutant vaccine
Vaccine Information
  • Vaccine Name: Francisella tularensis FTL0552 mutant vaccine
  • Target Pathogen: Francisella tularensis
  • Target Disease: Tularemia
  • Vaccine Ontology ID: VO_0002842
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • FTL0552 gene engineering:
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: A FTL0552 mutant is attenuated in mice (Sammons-Jackson et al., 2008).
  • Efficacy: A FTL0552 mutant provided partial protection in mice from challenge with wild type Francisella tularensis SchuS4 (Sammons-Jackson et al., 2008).
  • Host Ccl2 response
    • Description: LVS induced a significantly higher MCP-1 (Ccl2) response in mice lung homogenates as compared to FTL0552 mice beginning day 3 after infection (Sammons-Jackson et al., 2008).
    • Detailed Gene Information: Click Here.
  • Host Ifng (Interferon gamma) response
    • Description: LVS induced a significantly higher IFN-gamma response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
    • Detailed Gene Information: Click Here.
  • Host IL-6 response
    • Description: LVS induced a significantly higher IL-6 response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
    • Detailed Gene Information: Click Here.
  • Host Il12b response
    • Description: An FTL0552 mutant induced significantly elevated levels of IL-12 in C57BL/6 mice lung homogenates by day 7 post infection compared to LVS (Sammons-Jackson et al., 2008).
    • Detailed Gene Information: Click Here.
  • Host TNF-alpha response
    • Description: LVS induced a significantly higher TNF-alpha response in mice lung homogenates as compared to FTL0552 mice beginning day 5 after infection (Sammons-Jackson et al., 2008).
    • Detailed Gene Information: Click Here.
References
Sammons-Jackson et al., 2008: Sammons-Jackson WL, McClelland K, Manch-Citron JN, Metzger DW, Bakshi CS, Garcia E, Rasley A, Anderson BE. Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS). DNA and cell biology. 2008; 27(7); 387-403. [PubMed: 18613792].