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Vaccine Detail

Francisella tularensis guaA mutant vaccine

Vaccine Information

Vaccine Name: Francisella tularensis guaA mutant vaccine
Target Pathogen: Francisella tularensis
Target Disease: Tularemia
Vaccine Ontology ID: VO_0002845
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
guaA gene engineering:
- Type: Gene mutation
- Description: This guaA mutant is from Francisella tularensis (Santiago et al., 2009).
- Detailed Gene Information: Click Here.
Immunization Route: Intraperitoneal injection (i.p.)

Host Response

Mouse Response

Persistence: A guaA mutant is attenuated in mice (Santiago et al., 2009).
Efficacy: A guaA mutant induces significant protection in mice from challenge with wild type F. tularensis (Santiago et al., 2009).

References

Santiago et al., 2009: Santiago AE, Cole LE, Franco A, Vogel SN, Levine MM, Barry EM. Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes. Vaccine. 2009; 27(18); 2426-2436. [PubMed: 19368784].