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Vaccine Detail
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Francisella tularensis IglB mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis IglB mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Product Name: KKF235
- Vaccine Ontology ID: VO_0002847
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- IglB
gene engineering:
- Type: Gene mutation
- Description: This IgIB mutant is from Francisella tularensis (Yu et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: Oral immunization
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| Host Response |
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Mouse Response
- Persistence: An IglB mutant is attenuated in mice (Yu et al., 2010).
- Efficacy: An IglB mutant induces significant protection in mice from challenge with wild type F. tualrensis U112, LVS, and SchuS4 (Yu et al., 2010).
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| References |
Yu et al., 2010: Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clinical and vaccine immunology : CVI. 2010; 17(2); 215-222. [PubMed: 20016043].
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