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Vaccine Detail

Francisella tularensis sodC mutant vaccine

Vaccine Information

Vaccine Name: Francisella tularensis sodC mutant vaccine
Target Pathogen: Francisella tularensis
Target Disease: Tularemia
Vaccine Ontology ID: VO_0002853
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
sodC gene engineering:
- Type: Gene mutation
- Description: This sodC mutant is from Francisella tularensis (Melillo et al., 2009).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Mouse Response

Persistence: A sodC mutant is attenuated in mice (Melillo et al., 2009).
Efficacy: A sodC mutant induces protection in mice from challenge with wild type F. tularensis (Melillo et al., 2009).

References

Melillo et al., 2009: Melillo AA, Mahawar M, Sellati TJ, Malik M, Metzger DW, Melendez JA, Bakshi CS. Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species. Journal of bacteriology. 2009; 191(20); 6447-6456. [PubMed: 19684141].