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Vaccine Detail
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Francisella tularensis wbtA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis wbtA mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Vaccine Ontology ID: VO_0002854
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- wbtA
gene engineering:
- Type: Gene mutation
- Description: This wbtA mutant is from Francisella tularensis (Sebastian et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intradermal injection (i.d.)
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| Host Response |
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Mouse Response
- Persistence: A wbtA mutant is attenuated in mice (Sebastian et al., 2007).
- Efficacy: A wbtA mutant induces significant protection in mice from challenge with wild type F. tularensis (Sebastian et al., 2007).
- Host Ighv1-9 response
- Description: The titer of immunoglobulin G (IgG) antibodies directed toward the surface-exposed protein antigens in anti-LVS wbtA antisera was determined to be 8,000 + 1,849, fourfold higher than the titer for LVS-immunized mice. The IgG2a subclass predominated among the IgG subtypes analyzed (Sebastian et al., 2007).
- Detailed Gene Information: Click Here.
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| References |
Sebastian et al., 2007: Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infection and immunity. 2007; 75(5); 2591-2602. [PubMed: 17296751].
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