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Vaccine Detail

Escherichia coli ler mutant vaccine
Vaccine Information
  • Vaccine Name: Escherichia coli ler mutant vaccine
  • Target Pathogen: Escherichia coli
  • Target Disease: Hemorrhagic colitis
  • Vaccine Ontology ID: VO_0002838
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • ler gene engineering:
    • Type: Gene mutation
    • Description: This ler mutant is from Escherichia coli (Liu et al., 2009).
    • Detailed Gene Information: Click Here.
  • ler gene engineering:
    • Type: Gene mutation
    • Description: This ler mutant is from Escherichia coli (Liu et al., 2009).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: A ler mutant is attenuated in mice (Liu et al., 2009).
  • Efficacy: Suckling mice born to mothers immunized with a ler mutant were protected from challenge with wild type E. coli (Liu et al., 2009).
References
Liu et al., 2009: Liu J, Sun Y, Feng S, Zhu L, Guo X, Qi C. Towards an attenuated enterohemorrhagic Escherichia coli O157:H7 vaccine characterized by a deleted ler gene and containing apathogenic Shiga toxins. Vaccine. 2009; 27(43); 5929-5935. [PubMed: 19682616].