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Vaccine Detail

Equid herpesvirus gI mutant vaccine

Vaccine Information

Vaccine Name: Equid herpesvirus gI mutant vaccine
Target Pathogen: Equid herpesvirus
Target Disease: Equine Rhinopneumonitis
Vaccine Ontology ID: VO_0002956
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
gI gene engineering:
- Type: Gene mutation
- Description: This gI mutant is from Equid herpesvirus 1 (Tsujimura et al., 2006).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Mouse Response

Persistence: A gI mutant is attenuated in mice (Tsujimura et al., 2006)
Efficacy: A gI mutant induces significant protection in mice from challenge with wild type EHV (Tsujimura et al., 2006).

References

Tsujimura et al., 2006: Tsujimura K, Yamanaka T, Kondo T, Fukushi H, Matsumura T. Pathogenicity and immunogenicity of equine herpesvirus type 1 mutants defective in either gI or gE gene in murine and hamster models. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2006; 68(10); 1029-1038. [PubMed: 17085880].