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Vaccine Detail
Borrelia burgdorferi fla mutant vaccine |
Vaccine Information |
- Vaccine Name: Borrelia burgdorferi fla mutant vaccine
- Target Pathogen: Borrelia burgdorferi
- Target Disease: Lyme Disease
- Vaccine Ontology ID: VO_0002809
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- fla
gene engineering:
- Type: Gene mutation
- Description: This fla mutant is from Borrelia burgdorferi (Sadziene et al., 1996).
- Detailed Gene Information: Click Here.
- Immunization Route: Intradermal injection (i.d.)
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Host Response |
Mouse Response
- Persistence: A fla mutant is attenuated in SCID mice (Sadziene et al., 1996).
- Efficacy: A fla mutant induces protection in mice from challenge with wild type B. burgdorferi 28 days after inoculation (Sadziene et al., 1996).
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References |
Sadziene et al., 1996: Sadziene A, Thompson PA, Barbour AG. A flagella-less mutant of Borrelia burgdorferi as a live attenuated vaccine in the murine model of Lyme disease. The Journal of infectious diseases. 1996; 173(5); 1184-1193. [PubMed: 8627071].
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