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Vaccine Detail

Bordetella bronchiseptica aroA/trpE mutant vaccine
Vaccine Information
  • Vaccine Name: Bordetella bronchiseptica aroA/trpE mutant vaccine
  • Target Pathogen: Bordetella bronchiseptica
  • Target Disease: Infectious bronchitis, kennel cough
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • aroA gene engineering:
    • Type: Gene mutation
    • Description: This aroA/trpE mutant is from Bordetella bronchiseptica (McArthur et al., 2003).
    • Detailed Gene Information: Click Here.
  • trpE gene engineering:
    • Type: Gene mutation
    • Description: This aroA/trpE mutant is from Bordetella bronchiseptica (McArthur et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: An aroA/trpE mutant is attenuated in mice (McArthur et al., 2003).
  • Efficacy: An aroA/trpE mutant induces significant protection from challenge with wild type B. bronchiseptica (McArthur et al., 2003).
References
McArthur et al., 2003: McArthur JD, West NP, Cole JN, Jungnitz H, Guzmán CA, Chin J, Lehrbach PR, Djordjevic SP, Walker MJ. An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. FEMS microbiology letters. 2003; 221(1); 7-16. [PubMed: 12694904].