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Vaccine Detail

Salmonella Enteritidis guaBA/clpP mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Enteritidis guaBA/clpP mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Product Name: CVD 1941
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaA gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaB from S. enteritidis str. P125109 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: A guaBA/clpP mutant is attenuated in mice (Tennant et al., 2011).
  • Efficacy: A guaBA/clpP mutant induces protection in mice from challenge with wild type Salmonella Enteritidis. The vaccine efficacy is 76% (Tennant et al., 2011).
  • Host IgG response
    • Description: Immune responses induced included high levels of serum IgG anti-lipopolysaccharide (LPS), with titers increasing progressively during the immunization schedule. For mice immunized with attenuated S. Enteritidis vaccine candidates, there was a trend of higher seroconversion rates after the first dose (26 days after immunization) in mice that received CVD 1941 than for those immunized with CVD 1943, which was statistically significant for anti-FliC (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
References
Tennant et al., 2011: Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM. Engineering and pre-clinical evaluation of attenuated non-typhoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infection and immunity. 2011; ; . [PubMed: 21807911].