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Vaccine Detail

Burkholderia pseudomallei asd mutant vaccine
Vaccine Information
  • Vaccine Name: Burkholderia pseudomallei asd mutant vaccine
  • Target Pathogen: Burkholderia pseudomallei
  • Target Disease: Melioidosis
  • Vaccine Ontology ID: VO_0002826
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • asd gene engineering:
    • Type: Gene mutation
    • Description: This asd mutant is from Burkholderia pseudomallei (Norris et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Persistence: An asd mutant is highly attenuated in mice (Norris et al., 2011).
  • Efficacy: An asd mutant induces protection against challenge with wild type B. pseudomallei (Norris et al., 2011).
References
Norris et al., 2011: Norris MH, Propst KL, Kang Y, Dow SW, Schweizer HP, Hoang TT. The Burkholderia pseudomallei {Delta}asd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice. Infection and immunity. 2011; ; . [PubMed: 21807903].