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Vaccine Detail

Edwardsiella tarda aroC/slyA mutant vaccine
Vaccine Information
  • Vaccine Name: Edwardsiella tarda aroC/slyA mutant vaccine
  • Target Pathogen: Edwardsiella tarda
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Zebra fish
  • slyA gene engineering:
    • Type: Gene mutation
    • Description: An aroC and slyA mutant is attenuated in zebra fish. This mutant is also protective against challenge from wild type E. tarda, resulting in a relative percent survival of 80.1% (Xiao et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Fish Response

  • Persistence: This aroC/slyA mutant is attenuated in zebra fish (Xiao et al., 2011).
  • Efficacy: This aroC/slyA mutant is protective in zebra fish against challenge with wild type E. tarda. The percent relative survival is 80.1% (Xiao et al., 2011).
References
Xiao et al., 2011: Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda. Letters in applied microbiology. 2011; ; . [PubMed: 21777261].