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Vaccine Detail

Francisella tularensis clpB mutant vaccine
Vaccine Information
  • Vaccine Name: Francisella tularensis clpB mutant vaccine
  • Target Pathogen: Francisella tularensis
  • Target Disease: Tularemia
  • Vaccine Ontology ID: VO_0002841
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpB gene engineering:
    • Type: Gene mutation
    • Description: This clpB mutant is from Francisella tularensis (Conlan et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intradermal injection (i.d.)
Host Response

Mouse Response

  • Persistence: A clpB mutant is attenuated in mice (Conlan et al., 2010).
  • Efficacy: A clpB mutant induces significant protection in mice from challenge with wild type F. tularensis (Conlan et al., 2010).
References
Conlan et al., 2010: Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A. Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization. Vaccine. 2010; 28(7); 1824-1831. [PubMed: 20018266].