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Vaccine Detail

Mycobacterium tuberculosis RD1/panCD mutant vaccine
Vaccine Information
  • Vaccine Name: Mycobacterium tuberculosis RD1/panCD mutant vaccine
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Vaccine Ontology ID: VO_0002787
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • RD1 gene engineering:
    • Type: Gene mutation
    • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
    • Detailed Gene Information: Click Here.
  • panC gene engineering:
    • Type: Gene mutation
    • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
    • Detailed Gene Information: Click Here.
  • panD gene engineering:
    • Type: Gene mutation
    • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
    • Detailed Gene Information: Click Here.
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Persistence: An RD1/panCD mutant is attenuated in mice (Sambandamurthy et al., 2006).
  • Efficacy: An RD1/panCD mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Sambandamurthy et al., 2006).
  • Host Ifng (Interferon gamma) response
    • Description: At the 10-day time point, substantial increases (relative to naive mice) were detected in IFN-γ positive CD4 and CD8 lung cells taken from the vaccinated mice (Sambandamurthy et al., 2006).
    • Detailed Gene Information: Click Here.
  • Information about this animal model: Mouse Model for TB research
References
Sambandamurthy et al., 2006: Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR Jr. Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine. 2006; 24(37-39); 6309-6320. [PubMed: 16860907].