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Vaccine Detail

Salmonella Typhimurium wecA mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium wecA mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002914
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • wecA gene engineering:
    • Type: Gene mutation
    • Description: This wecA mutant is from Salmonella Typhimurium (Gilbreath et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A wecA mutant (DSM645) is attenuated in C57BL/6J mice through i.p. and oral immunization (Gilbreath et al., 2011).
  • Efficacy: A wecA mutant (DSM645) protects against challenge with S. typhimurium strains TML and SL1344 30 days after immunization (Gilbreath et al., 2011).
References
Gilbreath et al., 2011: Gilbreath JJ, Colvocoresses Dodds J, Rick PD, Soloski MJ, Merrell DS, Metcalf ES. Enterobacterial Common Antigen Mutants of Salmonella enterica serovar Typhimurium Establish a Persistent Infection and Provide Protection Against Subsequent Lethal Challenge. Infection and immunity. 2011; ; . [PubMed: 22025511].