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Vaccine Detail

Actinobacillus pleuropneumoniae apxIA mutant vaccine
Vaccine Information
  • Vaccine Name: Actinobacillus pleuropneumoniae apxIA mutant vaccine
  • Target Pathogen: Actinobacillus pleuropneumoniae
  • Target Disease: porcine pleuropneumonia
  • Vaccine Ontology ID: VO_0002766
  • Type: Live, attenuated vaccine
  • Status: Research
  • apxIA gene engineering:
    • Type: Gene mutation
    • Description: This apxIA mutant is from Actinobacillus pleuropneumoniae (Xu et al., 2006).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Pig Response

  • Persistence: An apxIA mutant is attenuated in pigs (Xu et al., 2006).
  • Efficacy: An apxIA mutant offered a level of cross-serovar protection against A. pleuropneumoniae infection in pigs (Xu et al., 2006).

Mouse Response

  • Persistence: An apxIA mutant is attenuated in mice (Xu et al., 2006).
  • Efficacy: An apxIA mutant offered a level of cross-serovar protection against A. pleuropneumoniae infection in mice (Xu et al., 2006).
References
Xu et al., 2006: Xu F, Chen X, Shi A, Yang B, Wang J, Li Y, Guo X, Blackall PJ, Yang H. Characterization and immunogenicity of an apxIA mutant of Actinobacillus pleuropneumoniae. Veterinary microbiology. 2006; 118(3-4); 230-239. [PubMed: 16930871].